In response, the government had "urgently" sent 200,000 doses of influenza A(H1N1) vaccine to the region since Sunday's death in a bid to contain the virus, China's health ministry said in a statement on its website.

"An influenza A(H1N1) sufferer in the region died after efforts to save the sufferer failed," it said.

"This is our first domestic report of a swine flu death," said the statement, which gave no further details on the victim.

However, state-run Xinhua news agency said in a report from the Tibetan regional capital Lhasa that the victim was an 18-year-old female who entered a hospital in the city on Saturday with severe flu symptoms.

China -- hit hard in the past by bird flu and Severe Acute Respiratory Syndrome (SARS) -- took swift and tough measures against the virus when it first emerged in the Americas.

This included strictly quarantining scores of foreign tourists and students merely for arriving on flights on which a virus sufferer was found.

But China has warned of a spike in cases -- and deaths -- during the winter flu season.

The health ministry said last month that "tens of millions" of people in the world's most populous country could get the virus in the coming months, adding that fatalities would be "unavoidable".

The health ministry released a separate statement on its website after reporting the Tibet death, warning of a growing risk from the disease.

"High-risk populations that already have underlying health conditions face especially great danger," it said.

However, in an apparent attempt to head off any panic over the fatality, it also stressed that authorities had reacted proactively to the disease and put in place systems allowing them to move rapidly against any outbreak.

The ministry statement also said China had now confirmed a total of 21,453 cases since swine flu first emerged, including 13 people who remained in serious condition.

China began mass vaccinations against swine flu last month, making it one of the first nations to start inoculating its population against the virus.

It has been at the forefront of efforts to develop vaccines, with several Chinese pharmaceutical companies already receiving government approval for versions they had developed.

However, it has warned that demand would likely exceed supply.

The health ministry has said it plans to vaccinate 65 million people, or five percent of the country's total population of 1.3 billion, before year's end.

It said late last month that China would have a stockpile of 26 million swine flu vaccine shots by the end of October, with that number eventually surging to 100 million, but not before year's end.

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