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Becoming human: An ancient genome perspective
Events in modern human prehistory that have increased overall population fitness, in turn supporting further survival and expansion of the global modern human population
Becoming human: An ancient genome perspective
by Simon Mansfield
Sydney, Australia (SPX) Mar 04, 2024

In a commentary published in the 50th anniversary issue of Cell, Prof. FU Qiaomei and E. Andrew Bennett of the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP), Chinese Academy of Sciences, delve into how paleogenomics has revolutionized our understanding of human evolution. Their work, "Ancient genomes and the evolutionary path of modern humans," published on February 29, emphasizes the crucial role ancient DNA plays in tracing the origins and evolution of modern humans.

The fascination with human origins is a universal trait, intertwined deeply within various global belief systems. Traditional approaches to unraveling our past, such as archeological and paleoanthropological studies, have significantly advanced our knowledge about the emergence of modern human characteristics and behaviors. Yet, the advent of genomics, particularly the sequencing of the first human genome over two decades ago, introduced a new dimension to these inquiries, offering comparative insights that highlight the genetic nuances distinguishing humans from our closest relatives, the great apes.

Despite the progress, a direct comparison between modern humans and chimpanzees-separated by approximately six million years of evolution-proved insufficient for a nuanced understanding of the recent evolutionary developments. This gap has been bridged by the emergence of paleogenomics, facilitated by the sequencing of early modern human and archaic genomes, including those of Neanderthals and Denisovans. This advancement has enabled scientists to trace the genetic changes more precisely, which underlie the distinctive traits of modern humans.

FU and Bennett outline two primary investigative approaches within paleogenomics. The first, a direct method, compares modern and archaic human genome sequences to identify unique genetic changes in modern humans. The second, an indirect approach, reconstructs the life histories of archaic and early modern human populations through ancient DNA, offering insights into past behaviors, population dynamics, and adaptations.

However, both methods face challenges, notably the incomplete understanding of the genetic diversity within archaic and early modern human populations. For instance, the discovery that alleles once thought unique to archaic genomes are also present in modern populations from diverse regions, particularly Africa, underscores the complexity of human evolution.

Despite these obstacles, paleogenomics has yielded significant findings. For example, both early modern humans and Neanderthals practiced female exogamy, but early modern humans maintained a greater genetic diversity.

This diversity, alongside the benefits of belonging to a larger, interconnected population network, may explain the differing fates of early modern and archaic human populations. The commentary also highlights how ancient DNA has revealed adaptations to local environments, diets, and innovations, such as lactase persistence following cattle domestication.

FU and Bennett's review underscores the invaluable contribution of ancient genetic data to understanding human evolution. By integrating findings from paleogenomics with those from paleoanthropology and archaeology, their work offers a comprehensive view of our origins, emphasizing the nuanced, multifaceted nature of human evolution.

This exploration into our past not only illuminates the evolutionary path that led to modern humans but also underscores the vast genomic diversity lost over millennia. It highlights the importance of ancient DNA studies in piecing together the puzzle of human origins, promising further discoveries that will continue to enrich our understanding of what it means to be human.

Research Report:Ancient genomes and the evolutionary path of modern humans

Related Links
Institute of Vertebrate Paleontology and Paleoanthropology
All About Human Beings and How We Got To Be Here

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