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Experts question use of Tamiflu: report

Netherlands reports third mutant swine flu death
The Hague (AFP) Dec 8, 2009 - A third patient in the Netherlands infected by a mutant strain of the swine flu virus has died, the country's health and environment institute said Tuesday. The Netherlands has seen eight cases of the mutated A(H1N1) virus, including the three fatalities, but the strain is not spreading, the institute said. "(The latest fatality) was an adult woman who was already ill," institute spokesman Harold Wychgel said, without giving the date of her death. "She had been treated for flu for some time and during treatment built up a resistance to Tamiflu," one of the main anti-flu drugs, he said. "There is no cause for panic." A total of 42 people have died in the Netherlands after contracting the H1N1 virus, and nearly 2,000 have been hospitalised since April. France, Spain and Norway have all reported deaths related to the mutated form of the virus.
by Staff Writers
London (AFP) Dec 8, 2009
Experts question the effectiveness of antiviral drug Tamiflu commonly used against the swine flu virus spreading across the globe, according to a study reported in Britain Tuesday.

An investigation by the British Medical Journal and Channel 4 News acknowledges that the drug oseltamivir, which trades as Tamiflu, has "a modest effect in reducing flu symptoms and infectivity in otherwise healthy adults."

But "researchers say there is insufficient published data to know if oseltamivir reduces complications in otherwise healthy adults," the media groups said in a joint statement.

Channel 4 News was to air the investigation Tuesday.

The use of flu drugs like oseltamivir has increased dramatically since the A(H1N1), or swine flu, pandemic began in April 2009, with government rushing to stockpile treatments while persuading people to have vaccinations.

The global death toll since the virus was uncovered in April approached 8,770 in early December, with confirmed infections in 207 countries, according to World Health Organisation figures.

Claims about the effectiveness of drugs like Tamiflu against flu complications have been a key factor in governments' choosing to spend millions of dollars to hoard them, the British Medical Journal and Channel 4 said.

The British government has spent about 500 million pounds (813.9 million dollars) on such drugs, they said.

But research on the drugs by scientists from Australia's Bond University was hampered by a "paucity of good data" available from Swiss pharmaceutical giant Roche that produces oseltamivir.

"As a result, they conclude that they have no confidence in claims that oseltamivir reduces the risk of complications of influenza in otherwise healthy adults, and believe it should not be used in routine control of seasonal influenza."

The researchers called on governments to set up studies to monitor the safety of drugs like Tamiflu, which are called neuraminidase inhibitors.

A team from the University of Birmingham concluded meanwhile that oseltamivir may reduce the risk of pneumonia in otherwise healthy people who contract flu.

"However, the absolute benefit is small, and side effects and safety should also be considered," the statement said.

Professor Nick Freemantle from the University of Birmingham said he saw "very little evidence to support the widespread use of oseltamivir in the otherwise healthy population who are developing signs of influenza-like illness."

"We have remarkably few resources in this country to spend on pharmaceuticals on health and it's surprising to see such widespread use of oseltamivir," he said.

British Medical Journal editor-in-chief Fiona Godlee warned that the review left unresolved important questions about effectiveness of the drugs.

"Governments around the world have spent billions of pounds on a drug that the scientific community now finds itself unable to judge," she said.

Roche has estimated sales of 1.6 billion pounds this year alone from the drug, the statement said.

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Swine flu outbreak less severe than feared: study
Washington (AFP) Dec 8, 2009
The H1N1 flu outbreak appears to be less severe than earlier feared, according to a new study by US health experts who found fewer than expected hospitalizations or severe complications from the virus. The British and US-funded study by researchers at the Harvard School of Public Health (HSPH), which appears online in the journal PLoS Medicine, said the swine flu pandemic appears far "milder ... read more







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