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Pandemic virus could get nastier in year two: expert

UN agency fears swine, bird flu combination
A swine flu outbreak in turkeys in Chile raises fears that the new virus could combine with avian influenza and mutate into a more dangerous disease, a UN agency warned Thursday. The Food and Agriculture Organization (FAO) expressed concern that other poultry farms around the world could become infected with the A(H1N1) virus, which had until now only been detected in humans and pigs. "The current H1N1 virus strain is a mixture of human, pig and bird genes and has proved to be very contagious but no more deadly than common seasonal flu viruses," the Rome-based agency said in a statement. "However, it could theoretically become more dangerous if it adds virulence by combining with H5N1, commonly known as avian flu, which is far more deadly but harder to pass along among humans," it said. The FAO noted that Chile does not have avian influenza, also known as bird flu. However, it added, "In South-East Asia where there is a lot of the (avian) virus circulating in poultry, the introduction of H1N1 in these populations would be of a greater concern." Chilean authorities announced last week that they had discovered a swine flu outbreak in two turkey farms in the Valparaiso region, 160 kilometers (99 miles) west of Santiago, and that it was transmitted by humans. The FAO called for better monitoring of the health of animals and for farms to follow good farming practice guidelines, "including protecting farm workers if animals are sick and not allowing sick workers near animals." "The emergence of new influenza virus strains capable of affecting humans and domestic animals remains a broader, more general concern that is being closely monitored by FAO, the World Organisation for Animal Health and the World Health Organization," it said. Photo courtesy AFP.
by Staff Writers
Paris (AFP) Aug 27, 2009
The swine flu is unlikely to become more virulent as it spreads through the northern hemisphere this winter, but could re-emerge a year later in a more deadly form, a top expert said Thursday.

"We should get through the winter relatively easily, I don't think the virus will mutate before then," said John Oxford, a professor of virology at Britain's St Bartholomew's and the Royal London Hospital.

"There will be more people in hospital and more deaths, but essentially it will be the same virus we have experienced in the summer, just more of it," he told AFP in an interview.

After winter has passed, however, the pressures of natural selection could favour the emergence of more deadly strains of the A(H1N1) virus, Oxford explained.

"For the moment, the virus is running around the world finding lots of young people and infecting them. It is doing very nicely, thank you, why should it change?", he said by phone.

"But once the virus has infected about a third of the world's population -- which is what we expect -- it will find less 'susceptibles'. That is when mutants will have a selective advantage."

It would be a serious mistake to think that once the impending flu season is over, the danger will have passed, he added.

Oxford said he had just returned from Australia, where he met front-line doctors who were concerned about an emerging pattern in swine flu patients.

Whether they are people in high risk groups -- the obese, pregnant women, asthmatics -- or young adults with no underlying conditions, an alarming number of patients wind up in intensive care units.

"One minute they are OK in a hospital bed, the next minute they are in intensive care," he said.

There have been more than 100 confirmed deaths from the pandemic H1N1 strain in Australia, which is just emerging from the southern hemisphere winter.

Epidemiologists sifting through data from other countries have also found similar -- and disquieting -- patterns.

French epidemiologist Antoine Flahault reported a 100-fold increase, compared to seasonal flu, in the number of swine flu deaths in Mauritius and New Caledonia attributed directly to the virus itself rather than secondary bacterial infections or underlying conditions.

Many of those deaths were caused by acute respiratory disease syndrome (ARDS), which requires intensive-care treatment for an average of three weeks. Only 50 percent of ARDS patients survive.

earlier related report
Brazil tops global swine flu toll with 557 deaths: officials
Brazil now has 557 swine flu deaths, making it the country with the highest number of fatalities in the world from the disease, according to figures announced by the health ministry Wednesday.

The toll puts it ahead of the latest count from the United States, which as of August 20 had 522 swine flu deaths, according to the US Centers for Disease Control and Prevention.

Brazil's health ministry said in a statement the government was freeing up one billion dollars to buy 73 million doses of a new vaccine being developed against swine flu, as well as Tamiflu stocks, hospital equipment and diagnostic gear.

It added that the infection rate appeared to be diminishing in the country, which is about to exit the southern hemisphere winter at the end of this month.

The ministry stressed that, as a ratio of its population of 190 million, Brazil's mortality rate from the virus ranked 7th in the world.

Argentina, Chile, Costa Rica, Uruguay, Australia and Paraguay all had higher rates on that basis, it said, referring to data from the European Center for Disease Prevention and Control.

The United States, which has a population of 300 million, came 13th on the list.

The Americas is the worst-hit region in the world in terms of swine flu deaths, accounting for more than 90 percent of the global count given by the World Health Organization.

After Brazil and the United States, Argentina is the country to suffer the most, with at least 439 swine flu deaths.

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Give flu vaccine to nurses, chronic sick first: EU experts
Brussels (AFP) Aug 25, 2009
Pregnant women, health workers and people with underlying health problems should receive swine flu vaccines ahead of the rest of the population, EU experts recommended Tuesday. There was no call for children to be prioritised. A previous idea to include young people in the list of those to be vaccinated first "was abandoned", an EU source said, without giving a reason. "All persons ... read more







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