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EPIDEMICS
Scientists fight back in 'mutant flu' research row
by Staff Writers
Paris (AFP) Dec 21, 2011

Killer flu virus threat over-hyped: Dutch scientist
The Hague (AFP) Dec 21, 2011 - A top Dutch scientist heading a team which created a mutant killer flu virus Wednesday said the threat to global biosecurity is being overplayed, even if full research results are published.

"The threat to bio-security is not as big as everybody thinks," Ron Fouchier, whose team at the Rotterdam Erasmus Medical Centre announced the mutant version in September, told AFP.

"Recreating this virus is definitely not easy. You need highly-skilled people and a very large team, as well as specialised facilities to do this type of work," he said.

Two top scientific journals said Tuesday they were mulling whether to publish full details on how Dutch scientists mutated the H5N1 flu virus in order for it to pass from one mammal to another.

Researchers genetically altered the bird flu strain in a lab, making it airborne and likely to be contagious between humans for the first time.

The research has sparked fears that a pandemic causing millions of deaths could be triggered if it emerged in nature or fell into hands of bio-terrorists or rogue countries.

A US government science and advisory committee urged the US journal Science and the British journal Nature to withhold key details of Fouchier's team's research, so that people seeking to harm the public would not be able to manufacture the virus.

Fouchier however said his team believed publishing the full findings, including a detailed description of the mutated virus, how it becomes airborne and its migration patterns, could help save lives in case of an outbreak.

"These are important details that we need to get out very quickly. This is information that needs to be shared with countries where H5N1 viruses cause outbreaks so that the countries can now be on the lookout if these mutations arise," he said.

He said however his team would respect a recommendation by the US National Science Advisory Board for Biosecurity (NSABB) that the journals withhold key details on their work, saying redrafts of their findings had been re-submitted for approval before the board.

The H5N1 strain of avian influenza is fatal in 60 percent of human cases but only 350 people have so far died from the disease, largely because it cannot, yet, be transmitted between humans.


Leading virologists on Wednesday warned of censorship after a US bioterror watchdog asked scientific journals to withhold details of lab work that created a mutant strain of killer flu.

The controversy erupted on Tuesday when the US National Science Advisory Board for Biosecurity (NSABB) urged the world's two top journals to exclude key details before publishing the research papers.

In what is believed to be the first time it has made the recommendation, the government monitor cited an "extremely serious global health threat."

As the US-published Science and its counterpart in London, Nature, mulled the request, some experts said the NSABB request was an over-reaction.

Others said it could set a worrying precedent for the free flow of information -- a vital component in scientific advance.

"It's going to sully scientific communication if, for spurious concern about biological warfare, little groups of self-appointed people start censoring," said John Oxford, a professor at London Queen Mary's School of Medicine and Dentistry.

"I know they call it 'redacted' or some such, but it's pure censorship," he said in an interview with AFP.

"It's censorship of a high level, and if that starts coming into the scientific arena, we will not know where we are."

In a blog, Vincent Racaniello, a professor of microbiology at Columbia University Medical Center in New York, said, "this is a bad day for virology, and for science in general.

"The decision by the NSABB sets a precedent for censoring future experimental results whose wide dissemination would benefit, not harm, humanity."

Sparking the storm were a paper submitted to Science by a team led by Ron Fouchier at the Erasmus Medical Centre in Rotterdam, and another sent to Nature by virologists led by Yoshihiro Kawaoka of the University of Wisconsin and the University of Tokyo, which reportedly showed the same result.

Both teams of scientists created a man-made form of the H5N1 influenza virus in the goal of figuring out what makes the avian pathogen tick.

Circulating among poultry, H5N1 leapt to humans in 1997, killing more than one in every two people that it infected.

Even though the virus was extremely lethal, it was not very contagious. It holed up in the bottom of the lungs rather than the upper airways, where viruses are spread by sneezing and coughing.

As a result, there have been only 573 documented cases of H5N1, although 336 have been fatal, according to the UN's World Health Organisation (WHO).

The lab-made pathogen reportedly swept away the mainstream concept of H5N1's lethality-versus-spreadability balance.

Tested on ferrets, it turned out to be both deadly and contagious. How much, though, has not emerged.

NSABB chair Paul Keim, a microbial geneticist, told the AAAS Science Insider report last month that he had huge concerns.

"I can't think of another pathogenic organism that is as scary as this one," Keim was quoted as saying. "I don't think anthrax is scary at all compared to this."

In an interview with AFP on Wednesday, the Rotterdam team leader Fouchier said his paper had been redrafted in order to uphold the NSABB recommendations.

But, he argued, publishing the full findings could help save lives by giving insights into how the virus becomes airborne and spreads through human contact.

He denied that his work, carried out in an extremely secure Level Three biosafety lab, could be an off-the-shelf blueprint for terrorists.

Several killer viruses and germs, including the bacteria for anthrax and the plague, have already been genetically sequenced and their data placed in the public domain.

"Recreating this virus is definitely not easy. You need highly-skilled people and a very large team, as well as specialised facilities to do this type of work," Fouchier said.

Oxford said that, with billions of poultry around the world, there was a statistical probability that one day the same genetic alignment of H5N1 that was created artificially would crop up naturally.

"The biggest terrorist on this planet is Mother Nature. That's what we have to worry about, not someone sitting in a cave in Afghanistan," he said.

Jean-Claude Manuguerra of France's Pasteur Institute said censorship or filtering of data was unlikely to work on practical grounds, given the informal networks that exist among scientists.

And it posed ethical dilemmas.

"Who is going to set down the procedures for publication?" he asked. "And who would have access to the complete data?"

Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola




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US official says bird flu limits not 'censorship'
Washington (AFP) Dec 21, 2011 - Leading US health official Anthony Fauci on Wednesday rejected claims that the United States is censoring science by seeking to limit potentially dangerous bird flu information in major journals.

The controversy arose when two separate research teams -- one in the Netherlands and the other in the United States -- separately found ways to alter the H5N1 avian influenza so it could pass easily between mammals.

Until now, bird flu has been rare in humans, but particularly fatal in those who do get sick. H5N1 first infected humans in 1997 and has killed more than one in every two people that it infected, for a total of 350 deaths.

Based on fears that a deadly global pandemic could result if the mutant flu escaped a lab or if a terror group were to find out how to make it, a US advisory panel on Tuesday urged scientific journals to hold back key details.

The data "clearly has public health benefit but it has the potential to be used in nefarious ways by some people," said Fauci, who heads the National Institute of Allergy and Infectious Diseases.

The National Science Advisory Board for Biosecurity (NSABB), made up of 23 non-governmental experts, voted unanimously that studies should be published in the journals Science and Nature, but with limited information.

Fauci said that any "legitimate" researchers would be able to seek the full details for their own study.

"If their credentials are appropriate they will have access to that information. So it's not like classified information," he told AFP.

"It's only for those people who have a need to know and have a legitimate purpose for it, as opposed to just throwing it out there so that anybody can do whatever they want," he added.

"It's absolutely not censorship because if you are a scientist and you have the need to know... you will definitely get that information."

The two research teams were funded by grants from the National Institutes of Health, and are in the process of working out changes to their manuscripts with the journals Nature and Science.

Fauci also said that fears of what the mutant virus might do have been overblown. For instance, just because it could be passed easily between ferrets does not necessarily mean it could be as easily transmitted between humans.

"There is a little bit of an overreaction," he said, calling reports of a "monster virus" a "bit dramatic."

The real concern is that H5N1 might mutate in nature and become an influenza that humans could catch and transmit easily, so knowing what those flu features might look like is an important research and surveillance tool, he said.

"We could give that information to the people who are out of the field doing the surveillance, the health officials in Vietnam, Indonesia or China... so they will have a better chance of recognizing as the virus starts to evolve," he said.

"So the scientific question is very legitimate."

Fauci said the NSABB's request for redaction was the first time the advisory committee had made such an appeal, and acknowledged that it was not popular in all corners of the science world.

"There are many scientists who don't agree with the committee. So we need to re-look at what the rational for that decision was, so we can all get together in an open and a transparent way, come up with some more concrete guidelines of what needs to be looked in these cases," he said.

"That is going to trigger some interesting dialogue, I believe."



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EPIDEMICS
Hong Kong culls chickens to battle bird flu
Hong Kong (AFP) Dec 21, 2011
Hong Kong culled 17,000 chickens Wednesday and suspended live poultry imports for 21 days after three birds tested positive for the deadly H5N1 strain of bird flu virus. Health chief York Chow announced the measures late Tuesday after a dead chicken at the city's main wholesale market and two wild birds tested positive for the virus, which can be fatal to humans. Authorities raised the b ... read more


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