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EPIDEMICS
Smallpox stores stir controversy

Finland may halt swine flu vaccine over narcolepsy fears
Helsinki (AFP) Aug 24, 2010 - Finland's National Institute for Health and Wefare recommended Tuesday halting the use of the Pandemrix swine flu vaccine until a probe into a possible link to narcolepsy among children is concluded. "At the moment we are not having a (swine flu) epidemic, so there is no immediate need for vaccination," the agency said in a statement. "Besides, major parts of the population are protected against the swine flu virus either through vaccination or or after having swine flu," it added.

The National Institute for Health and Wefare (THL) has received six reports of children known to have received the vaccine who have developed the chronic sleep disorder since the beginning of the year, it said, stressing however that "this is in line with the normal annual rate of narcolepsy cases." In addition, the agency said it was probing whether nine other cases of narcolepsy that had emerged since the beginning of 2010 could be linked to Pandemrix, which is produced by British pharmaceutical company GlaxoSmithKline. Last week, neighbouring Sweden's Medical Products Agency also opened an inquiry into the Pandemrix vaccine in response to reports of young people having developed symptoms consistent with narcolepsy after getting their shot.

But a cause-and-effect relationship between Pandemrix and narcolepsy is far from proven, with Finland's THL pointing out that the swine flu virus H1N1 itself could possibly cause the disease. "Child neurologists and THL will continue to study the connection (with Pandemrix), but this will take several months," the agency said. In the European Union alone, around 30 million people were vaccinated using Pandemrix. Sweden bought 18 million doses, which was enough to provide two injections for each of its 9.3 million inhabitants. According to Finland's National Health Institute, 2.5 million Finns were vaccinated against swine flu. Some 750 showed side effects, namely fevers, headaches and coughing, and one case was linked to narcolepsy.
by Emmarie Huetteman, Medill News Service
Washington (UPI) Aug 24, 2010
With this year marking 30 years since smallpox was declared eradicated, the World Health Organization is working to finish the job.

In preparation for next year's World Health Assembly meeting, the WHO is reviewing the current research on the virus -- considered one of the most devastating in history -- to schedule its destruction.

In 2006, the WHO set a deadline for the destruction of all stores of the smallpox virus worldwide: June 30, 2010. It wasn't the first deadline and it won't be the last. In 2007, the WHO decided to stall, delaying setting another deadline until 2011.

The culprit for the delay has a familiar face. Despite the 1996 assembly vote to destroy the virus, the United States and Russia, which possess the only known stocks, haven't complied, arguing there is more research to be done and asking for more time.

Dr. Donald A. Henderson, who directed the WHO's successful smallpox eradication campaign from 1966-77, said other countries see this refusal as a patronizing display of arrogance.

"Here we are, it's Big Brother Russia and Big Brother United States telling us what to do," said Henderson, who is a distinguished scholar at the Center for Biosecurity at the University of Pittsburgh.

But Henderson disagrees with the "big brother" characterization. "We were the ones who really suffered for this disease and worked to get rid of it," he said.

Henderson said the American and Russian labs came into possession of the smallpox virus during the beginning of the eradication effort in the 1960s. They volunteered to help with the routine process of diagnosing the disease, which is fatal as much as 30 percent of the time.

While there were other labs that worked with smallpox, Henderson said the WHO became concerned with lax security procedures and wanted to better contain the virus and regulate research.

The WHO recommended limiting the stores to those in Atlanta and Russia in 1994. Henderson said some countries sent their stocks to the approved labs, while others destroyed their stores of the virus.

In 2005, many were alarmed when the United States revealed plans to genetically engineer and further experiment with the smallpox virus. The announcement added urgency to opponents' calls for the WHO to strengthen its oversight of smallpox research, which they felt was lacking.

Evidenced by the World Health Assembly's vote and reaffirmations at subsequent meetings, there is widespread support for destroying existing stocks of the virus.

Edward Hammond, director of the Sunshine Project, which advocates against misuse of biotechnology, wrote in 2007 that vaccines and diagnostic tests are effective enough to merit halting research on smallpox.

He said the United States' continued refusal to destroy the contagious, sometimes fatal, virus as a matter of national security sends other countries the message that they, too, must obtain it for their security. It is unknown whether illicit stores of smallpox exist outside Atlanta and Russia.

"The decades old eradication job of WHO will be completed and the world will be safer, when the U.S. and Russian smallpox virus stocks are finally destroyed," Hammond wrote.

In 2007, Dr. John O. Agwunobi, who was assistant secretary for health at the U.S. Department of Health and Human Services, wrote it would be "short-sighted" to destroy stores of the virus.

He said further research could yield an effective treatment, of which there is none currently, as well as improved diagnostic tests and vaccines.

The population is particularly vulnerable because it's largely unvaccinated, Agwunobi said. The United States stopped vaccinating against smallpox in 1972.



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